Expiratory variability index is associated with asthma risk, wheeze and lung function in infants with recurrent respiratory symptoms

ERJ Open Research, 2020

Authors: Ville-Pekka Seppä, Javier Gracia-Tabuenca, Anne Kotaniemi-Syrjänen, Kristiina Malmström, Anton Hult, Anna Pelkonen, Mika J. Mäkelä, Jari Viik, L. Pekka Malmberg

Recurrent respiratory symptoms are common in infants but the paucity of lung function tests suitable for routine use in infants is a widely acknowledged clinical problem. In this study we evaluated tidal breathing variability (expiratory variability index, EVI) measured at home during sleep using impedance pneumography (IP) as a marker of lower airway obstruction in 36 infants (mean age 12.8 [range 6-23] months) with recurrent respiratory symptoms. Lowered EVI was associated with lower lung function (VmaxFRC), higher asthma risk, and obstructive symptoms, but not with nasal congestion. EVI measured using IP is a potential technique for lung function testing in infants.

EVI compared with a) asthma risk groups, b) main symptoms and c) lung function

Read the whole article here: https://openres.ersjournals.com/content/6/4/00167-2020